How to enhance the precision and efficiency of drug screening? Collaboration with the Kobilka Institute for Innovative Drug Development
I. Kobilka Institute of Innovative Drug Discovery, KIIDD
The Kobilka Institute of Innovative Drug Discovery (KIIDD) is one of the first Nobel laureate laboratories established at The Chinese University of Hong Kong, Shenzhen. Led by Professor Brian K. Kobilka, recipient of the 2012 Nobel Prize in Chemistry, KIIDD is dedicated to translating fundamental scientific research into drug discovery.
II. Challenges in Drug Screening and Automated Solutions
During drug screening, researchers typically need to accurately transfer thousands of candidate compounds from compound libraries to assay plates and uniformly dispense cell suspensions into microplates to achieve standardized seeding. Traditional manual operations are not only time-consuming and labor-intensive but also struggle to ensure data accuracy and reproducibility, becoming a bottleneck for screening efficiency and experimental quality.
SC9210 SE After aspirate
To address these pain points, the KIIDD is exploring the introduction of the SC9210 SE 96-channel fully automated pipetting workstation from PRCXI to resolve core issues such as poor uniformity, high error rates, and low efficiency during experiments.
III. Core Advantages of the SC9210 Workstation
The PRCXI SC9210 Series Fully Automated Pipetting Workstation compresses manual operations that previously took days into just hours, significantly freeing up research personnel. Its pipetting CV (coefficient of variation) is stably controlled at ≤1.5% (20μl), markedly outperforming manual operations (>10%), ensuring data reliability from the source. The equipment incorporates specialized anti-cross-contamination design, substantially reducing false positive rates and effectively enhancing the accuracy of screening results.
Schematic Diagram of Microplate Wells in High-Throughput Drug Screening
In terms of throughput, the system features a 96-channel pipette head capable of dispensing a single 96-well plate in just 15 seconds. It can process up to 576 plates per day, achieving throughput 120 times faster than manual operations, making it perfectly suited for large-scale compound screening requirements.
Core Performance Overview:
Precision Control: Pipetting accuracy ±3 (at 20μl), with controllable precision error to ensure accurate dispensing.
Throughput Efficiency: 96-channel parallel processing enables tens of thousands of samples to be processed daily, significantly boosting efficiency.
Data Reliability: Fully automated recording and encrypted storage of all operations, supporting audit trails and data traceability.
Repeatability Assurance: Pre-experiment automatic pipette tip calibration with adaptive compensation for consumable variations, ensuring consistent protocol execution across time and personnel.
Process Standardization: ZWorks intelligent software automates steps including "dilution-mixing-dispensing-incubation," achieving standardized workflow operations.
IV. Conclusion
The SC9210 series fully automated pipetting workstations from PRCXI aim to deliver precise, efficient, and reliable performance, providing robust tool support for high-throughput drug screening at the KIIDD. Should you have related experimental needs, please feel free to contact us via private message. We will provide prompt service.